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10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"\041E\0431\044B\0447\043D\0430\044F \0442\0430\0431\043B\0438\0446\0430"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-unhide:no; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="1026"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--> </head> <body lang=RU style='tab-interval:35.4pt'> <div class=WordSection1> <p class=MsoNormal align=center style='text-align:center'><b><span lang=UK>ІНСТРУКЦІЯ<o:p></o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center'><b style='mso-bidi-font-weight: normal'><span lang=UK style='font-family:"Times New Roman CYR","serif"; mso-bidi-font-family:"Times New Roman"'>для медичного застосування лікарського засобу<o:p></o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center'><b style='mso-bidi-font-weight: normal'><span lang=UK style='font-family:"Times New Roman CYR","serif"; mso-bidi-font-family:"Times New Roman"'><o:p> </o:p></span></b></p> <h3 align=center style='text-align:center'><span lang=UK>АЦЕЛІЗИН</span></h3> <p class=MsoNormal align=center style='text-align:center'><b><span lang=UK>(ACELYSIN)<o:p></o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Склад:<o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><i><span lang=UK style='mso-bidi-font-weight:bold'>діюча речовина:</span></i><span lang=UK style='font-size:14.0pt'> </span><i style='mso-bidi-font-style:normal'><span lang=UK>ацелізин стерильний;<span style='mso-bidi-font-weight:bold;mso-bidi-font-style:italic'> <o:p></o:p></span></span></i></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>1 флакон містить ацелізину стерильного – 1 г;</span><i><span style='mso-ansi-language:RU;mso-bidi-font-weight: bold'><o:p></o:p></span></i></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK>Лікарська форма.</span></b><span lang=UK> Порошок для розчину для ін’єкцій.</span></p> <p class=MsoNormal style='text-align:justify'><i><span lang=UK style='mso-bidi-font-weight:bold'>Основні фізико-хімічні властивості</span><span lang=UK>:</span></i><span lang=UK> кристалічний порошок білого кольору без запаху або зі слабким специфічним запахом.</span></p> <p class=MsoNormal style='text-align:justify'><b><i><span lang=UK><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><b><span lang=UK>Фармакотерапевтична група.</span></b><span lang=UK> Інші аналгетики та антипіретики. Саліцилова кислота та її похідні. Код АТХ N02B A01.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Фармакологічні властивості.</span></i></b><i style='mso-bidi-font-style:normal'><span lang=UK> <o:p></o:p></span></i></p> <p class=MsoNormal style='text-align:justify'><i><span lang=UK>Фармакодинаміка.</span></i><span lang=UK> </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Ацелізин є ін’єкційною формою ацетилсаліцилової кислоти і має характерні для неї властивості, а також підвищує її біодоступність та аналгетичний ефект. Володіє аналгезуючою, протизапальною, жарознижувальною і антиагрегантною дією.</span></p> <p class=MsoBodyText><span lang=UK>Препарат інгібує циклооксигеназу, у результаті чого пригнічується синтез простагландинів і утворення тромбоксану А<sub>2</sub> у тромбоцитах. Зменшується здатність тромбоцитів і еритроцитів до склеювання і прилипання (адгезії) до ендотелію кровоносних судин. Знижуючи поверхневий натяг мембран еритроцитів, препарат полегшує їх деформування при проходженні через капіляри і покращує кровотік.</span></p> <p class=MsoNormal style='text-align:justify'><i><span lang=UK>Фармакокінетика. <o:p></o:p></span></i></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Препарат зв’язується з білками плазми на 80-90 %. Проникає у більшість тканин організму, у тому числі в синовіальну, цереброспінальну, перитонеальну рідини. У крові гідролізується, утворюючи ацетилсаліцилову кислоту і лізин. У печінці ацетилсаліцилова кислота перетворюється на саліцилову. Період напіввиведення ацетилсаліцилової кислоти становить 15-20 хвилин, саліцилової та її активних метаболітів – від 3-6 годин (малі дози) до 15-<span style='mso-spacerun:yes'> </span>30 годин (великі дози). Екскретується переважно нирками у незмінній формі (60 %) та у вигляді метаболітів.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=EN-US style='mso-ansi-language:EN-US'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><span lang=EN-US style='mso-ansi-language:EN-US'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><span lang=EN-US style='mso-ansi-language:EN-US'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK>Клінічні характеристики.<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span lang=UK>Показання.<o:p></o:p></span></i></b></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l2 level1 lfo3;tab-stops:list 18.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>Больовий синдром різного генезу (головний, вушний і зубний біль, болі у післяопераційному періоді, а також при міалгії, артралгії, невралгії, невритах, колікоподібних болях, при ревматичних захворюваннях);</span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l2 level1 lfo3;tab-stops:list 18.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>гарячкові стани;</span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l2 level1 lfo3;tab-stops:list 18.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>тромбофлебіт поверхневих вен;</span></p> <p class=MsoNormal style='margin-left:18.0pt;text-indent:-18.0pt;mso-list:l2 level1 lfo3; tab-stops:list 18.0pt'><![if !supportLists]><span lang=UK style='font-family: Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>профілактика і лікування післяопераційних тромбозів та емболій.</span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span lang=EN-US style='mso-ansi-language:EN-US'><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span lang=UK>Протипоказання.<o:p></o:p></span></i></b></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Гіперчутливість</span></span><span lang=UK> <span class=hps>до ацетилсаліцилової кислоти</span>, <span class=hps>інших саліцилатів</span> <span class=hps>або</span> <span class=hps>до будь-якого</span> <span class=hps>компоненту</span> <span class=hps>препарату.</span> </span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span class=hps><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span></span><![endif]><span lang=UK>Б<span class=hps>ронхіальна</span> <span class=hps>астма</span>, викликана <span class=hps>застосуванням</span> <span class=hps>саліцилатів</span> <span class=hps>або</span> <span class=hps>речовин</span> <span class=hps>з</span> <span class=hps>подібною дією</span>, <span class=hps>особливо</span> <span class=hps>НПЗЗ</span>, <span class=hps>в</span> <span class=hps>анамнезі.<o:p></o:p></span></span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Гострі</span></span><span lang=UK> <span class=hps>шлунково</span><span class=atn>-</span>кишкові <span class=hps>виразки</span>. </span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Геморагічний</span></span><span lang=UK> <span class=hps>діатез</span>.</span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Ниркова</span></span><span lang=UK> <span class=hps>недостатність</span> <span class=hps>важкого ступеня</span>.</span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Печінкова</span></span><span lang=UK> <span class=hps>недостатність</span> <span class=hps>важкого ступеня.</span> </span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Серцева</span></span><span lang=UK> <span class=hps>недостатність</span> <span class=hps>важкого ступеня.</span> </span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span class=hps><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span></span><![endif]><span class=hps><span lang=UK>Комбінація</span></span><span lang=UK> <span class=hps>з</span> <span class=hps>метотрексатом</span> <span class=hps>у</span> <span class=hps>дозуванні</span> <span class=hps>15</span> <span class=hps>мг/тиждень або</span> <span class=hps>більше.<o:p></o:p></span></span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15'><![if !supportLists]><span class=hps><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span></span><![endif]><span class=hps><span lang=UK>Комбінація</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>в</span> <span class=hps>протизапальних/жарознижуючих/ анальгезуючих</span> <span class=hps>дозах</span> і<span class=hps>з пероральними</span> <span class=hps>антикоагулянтами</span> <span class=hps>у хворих</span> <span class=hps>з гастродуоденальною</span> <span class=hps>виразкою</span> <span class=hps>в</span> <span class=hps>анамнезі.<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Взаємодія з іншими лікарськими засобами та інші види взаємодій. <o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><u><span lang=UK>Протипоказання</span></u></i></span><i style='mso-bidi-font-style:normal'><u><span lang=UK> <span class=hps>для</span> <span class=hps>одночасного застосування</span>. <o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>та метотрексату</span> <span class=hps>в</span> <span class=hps>дозах</span> <span class=hps>15</span> <span class=hps>мг/тиждень</span> <span class=hps>і більше</span> <span class=hps>підвищує</span> <span class=hps>гематологічну</span> <span class=hps>токсичність</span> <span class=hps>метотрексату</span> <span class=hps>(зниження</span> <span class=hps>ниркового</span> <span class=hps>кліренсу</span> <span class=hps>метотрексату</span> <span class=hps>протизапальними</span> <span class=hps>агентами</span> <span class=hps>і витіснення</span> <span class=hps>саліцилатами</span> <span class=hps>метотрексату зі</span> <span class=hps>зв’язку з</span> <span class=hps>білками</span> <span class=hps>плазми</span>). </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l7 level1 lfo15;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>з пероральними</span> <span class=hps>антикоагулянтами</span> <span class=hps>в</span> <span class=hps>протизапальних/жарознижуючих/анальгезуючих</span> <span class=hps>дозах</span> <span class=hps>пацієнтам</span> <span class=hps>з</span> <span class=hps>гастродуоденальними</span> <span class=hps>виразками</span> <span class=hps>в</span> <span class=hps>анамнезі</span>: <span class=hps>підвищений</span> <span class=hps>ризик</span> <span class=hps>кровотечі</span>. </span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><u><span lang=UK>Не</span></u></i></span><i style='mso-bidi-font-style:normal'><u><span lang=UK> <span class=hps>рекомендовані</span> <span class=hps>комбінації</span>. <o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>з пероральними</span> <span class=hps>антикоагулянтами</span> <span class=hps>в</span> <span class=hps>протизапальних/жарознижуючих/анальгезуючих</span> <span class=hps>дозах</span> <span class=hps>пацієнтам</span> <span class=hps>при</span> <span class=hps>відсутності</span> <span class=hps>гастродуоденальних</span> <span class=hps>виразок</span> <span class=hps>в</span> <span class=hps>анамнезі</span>: <span class=hps>підвищений</span> <span class=hps>ризик</span> <span class=hps>виникнення</span> <span class=hps>кровотечі</span>.</span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>з пероральними</span> <span class=hps>антикоагулянтами</span> <span class=hps>в</span> <span class=hps>антиагрегантних</span> <span class=hps>дозах</span> <span class=hps>пацієнтам</span> <span class=hps>з</span> <span class=hps>гастродуоденальними</span> <span class=hps>виразками</span> <span class=hps>в</span> <span class=hps>анамнезі</span>: <span class=hps>підвищений</span> <span class=hps>ризик</span> <span class=hps>кровотеч</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Одночасне</span></span><span lang=UK> <span class=hps>застосування з</span> <span class=hps>низькомолекулярним</span> <span class=hps>гепарином</span>, <span class=hps>нефракційним</span> <span class=hps>гепарином</span> <span class=hps>у пацієнтів похилого</span> <span class=hps>віку</span> <span class=hps>(старше</span> <span class=hps>65</span> <span class=hps>років</span>) незалежно <span class=hps>від</span> <span class=hps>дози</span> <span class=hps>гепарину</span> <span class=hps>і</span> <span class=hps>протизапальних/жарознижуючих/анальгезуючих</span> <span class=hps>доз</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>клопідогрелем</span> <span class=hps>(якщо немає</span> <span class=hps>затверджених</span> <span class=hps>показань</span> <span class=hps>до застосування</span> <span class=hps>даної комбінації</span> <span class=hps>у пацієнтів з</span> <span class=hps>гострим</span> <span class=hps>коронарним</span> <span class=hps>синдромом)</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>тиклопідином</span>, <span class=hps>з</span> <span class=hps>урикозуричними</span> <span class=hps>лікарськими</span> <span class=hps>засобами</span>.</span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>глюкокортикоїдами</span> <span class=hps>(крім</span> <span class=hps>замісної</span> <span class=hps>терапії</span>) <span class=hps>для</span> <span class=hps>протизапальних</span> <span class=hps>доз</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l1 level1 lfo16;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>пеметрекседом</span> <span class=hps>у пацієнтів</span> <span class=hps>з легкою та помірною</span> <span class=hpsatn>нирковою недостатністю (</span>кліренс <span class=hps>креатиніну</span> <span class=hps>між</span> <span class=hps>45</span> <span class=hps>мл/хв</span> <span class=hps>і</span> <span class=hps>80</span> <span class=hps>мл/хв</span>): підвищується <span class=hps>ризик</span> <span class=hps>токсичності</span> <span class=hps>пеметрекседу</span>. </span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><u><span lang=UK>Комбінації</span></u></i></span><i style='mso-bidi-font-style:normal'><u><span lang=UK>, <span class=hps>які слід</span> <span class=hps>застосовувати з</span> <span class=hps>обережністю</span>.<o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>При</span></span><span lang=UK> <span class=hps>застосуванні</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>та метотрексату</span> <span class=hps>в</span> <span class=hps>дозах менше</span> <span style='mso-spacerun:yes'> </span><span class=hps>15</span> <span class=hps>мг/тиждень</span> <span class=hps>підвищується</span> <span class=hps>гематологічна</span> <span class=hps>токсичність</span> <span class=hps>метотрексату</span> <span class=hps>(зниження</span> <span class=hps>ниркового</span> <span class=hps>кліренсу</span> <span class=hps>метотрексату</span> <span class=hps>протизапальними</span> <span class=hps>агентами</span> <span class=hps>і витіснення</span> <span class=hps>саліцилатами</span> <span class=hps>метотрексату зі</span> <span class=hps>зв’язку з</span> <span class=hps>білками</span> <span class=hps>плазми</span>). </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>з ібупрофеном</span> <span class=hps>перешкоджає</span> <span class=hps>необоротному</span> <span class=hps>інгібуванню тромбоцитів</span> <span class=hps>ацетилсаліциловою</span> <span class=hps>кислотою</span>. <span class=hps>Лікування</span> <span class=hps>ібупрофеном</span> <span class=hps>пацієнтів</span> <span class=hps>з ризиком</span> <span class=hps>кардіоваскулярних</span> <span class=hps>захворювань може</span> <span class=hps>обмежувати</span> <span class=hps>кардіопротекторну</span> <span class=hps>дію</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>та антикоагулянтів</span>, <span class=hps>тромболітиків/інших</span> <span class=hps>інгібіторів</span> <span class=hps>агрегації</span> <span class=hps>тромбоцитів/гемостазу</span> <span class=hps>підвищує</span> <span class=hps>ризик</span> <span class=hps>кровотечі</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>високих</span> <span class=hps>доз</span> <span class=hps>саліцилатів</span> <span class=hps>із НПЗЗ</span> <span class=hps>(завдяки</span> <span class=hps>взаємодоповнюючим</span> <span class=hps>ефектам</span>) <span class=hps>підвищується</span> <span class=hps>ризик</span> <span class=hps>виникнення</span> <span class=hps>виразок</span> <span class=hps>шлунково</span><span class=atn>-</span>кишкового <span class=hps>тракту</span> <span class=hps>і шлунково</span><span class=atn>-</span>кишкових <span class=hps>кровотеч</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>селективними</span> <span class=hps>інгібіторами</span> <span class=hps>зворотного захоплення</span> <span class=hps>серотоніну</span> <span class=hpsatn>(</span>включаючи <span class=hps>циталопрам</span>, <span class=hps>есціталопрам</span>, <span class=hps>флуоксетин</span>, <span class=hps>флувоксамін</span>, <span class=hps>пароксетин</span>, <span class=hps>сертралін</span>) <span class=hps>підвищує</span> <span class=hps>ризик</span> <span class=hps>розвитку</span> <span class=hps>шлунково</span><span class=atn>-</span>кишкової кровотечі <span class=hps>внаслідок можливого</span> <span class=hps>ефекту</span> <span class=hps>синергізму</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>дигоксином</span> <span class=hps>–</span> <span class=hps>концентрація</span> <span class=hps>останнього</span> <span class=hps>в</span> <span class=hps>плазмі</span> <span class=hps>підвищується</span> <span class=hps>внаслідок зниження</span> <span class=hps>ниркової</span> <span class=hps>екскреції</span>.</span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>високих</span> <span class=hps>доз</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>і</span> <span class=hps>протидіабетичних</span> <span class=hps>препаратів</span> <span class=hps>із групи</span> <span class=hps>похідних</span> <span class=hps>сульфонілсечовини</span> <span class=hps>посилює</span> <span class=hps>гіпоглікемічний</span> <span class=hps>ефект</span> <span class=hps>останніх</span> <span class=hps>за</span> <span class=hps>рахунок витіснення</span> <span class=hps>сульфонілсечовини</span>, <span class=hps>зв’язаної</span> <span class=hps>з</span> <span class=hps>білками</span> <span class=hps>плазми</span>, <span class=hps>ацетилсаліциловою кислотою</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Діуретичні</span></span><span lang=UK> <span class=hps>засоби</span> <span class=hps>в</span> <span class=hps>поєднанні</span> <span class=hps>з високими</span> <span class=hps>дозами</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>знижують</span> <span class=hps>клубочкову</span> <span class=hps>фільтрацію</span> <span class=hps>завдяки зниженню</span> <span class=hps>синтезу</span> <span class=hps>простагландинів</span> <span class=hps>у</span> <span class=hps>нирках</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>С<span class=hps>истемні</span> <span class=hpsatn>глюкокортикостероїди (</span>за <span class=hps>винятком</span> <span class=hps>гідрокортизону</span>, <span class=hps>який</span> <span class=hps>застосовують</span> <span class=hps>для</span> <span class=hps>замісної</span> <span class=hps>терапії</span> <span class=hps>при</span> <span class=hps>хворобі</span> <span class=hps>Аддісона</span>) <span class=hps>знижують</span> <span class=hps>рівень</span> <span class=hps>саліцилатів</span> <span class=hps>в</span> <span class=hps>крові.</span> <span class=hps>Застосування з</span> <span class=hps>кортикостероїдами</span> <span class=hps>підвищує</span> <span class=hps>ризик</span> <span class=hps>розвитку</span> <span class=hps>шлунково</span><span class=atn>-</span>кишкових <span class=hps>кровотеч</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Інгібітори</span></span><span lang=UK> <span class=hps>АПФ</span> <span class=hps>в</span> <span class=hps>поєднанні</span> <span class=hps>з високими</span> <span class=hps>дозами</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>спричиняють зниження</span> <span class=hps>фільтрації</span> <span class=hps>в</span> <span class=hps>клубочках</span> <span class=hps>внаслідок інгібування</span> <span class=hps>вазодилататорного</span> <span class=hps>ефекту</span> <span class=hps>простагландинів</span> і також<span class=hps> зниження</span> <span class=hps>антигіпертензивного</span> <span class=hps>ефекту.</span> </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span class=hps><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>вальпроєвою</span> <span class=hps>кислотою</span> <span class=hps>–</span> <span class=hps>ацетилсаліцилова</span> <span class=hps>кислота</span> <span class=hps>витісняє</span> <span class=hps>її</span> <span class=hps>зі зв’язку з</span> <span class=hps>білками</span> <span class=hps>плазми крові</span>, <span class=hps>підвищуючи</span> <span class=hps>токсичність</span> <span class=hps>останньої.<o:p></o:p></span></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Алкоголь</span></span><span lang=UK> <span class=hps>сприяє пошкодженню</span> <span class=hps>слизової</span> <span class=hps>оболонки</span> <span class=hps>шлунково</span><span class=atn>-</span>кишкового <span class=hps>тракту</span> <span class=hps>і</span> <span class=hps>пролонговує</span> <span class=hps>час</span> <span class=hps>кровотечі внаслідок</span> <span class=hps>синергізму</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span> <span class=hps>і</span> <span class=hps>алкоголю</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування</span></span><span lang=UK> <span class=hps>сечогінних</span> <span class=hps>лікарських</span> <span class=hps>засобів</span>, <span class=hps>інгібіторів</span> <span class=hps>АПФ</span>, <span class=hps>антагоністів</span> <span class=hps>рецепторів</span> <span class=hps>ангіотензину</span> <span class=hps>ІІ</span> <span class=hps>з</span> <span class=hps>протизапальними/жарознижувальними/анальгезуючими</span> <span class=hps>дозами</span> <span class=hps>ацетилсаліцилової</span> <span class=hps>кислоти</span>: <span class=hps>ризик</span> <span class=hps>гострої</span> <span class=hps>ниркової</span> <span class=hps>недостатності</span>. <span class=hps>На початку</span> <span class=hps>лікування необхідно</span> <span class=hps>переконатися</span>, <span class=hps>що у пацієнта</span> <span class=hps>немає</span> <span class=hps>зневоднення</span> <span class=hps>і постійно</span> <span class=hps>контролювати</span> <span class=hps>функції</span> <span class=hps>нирок</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>клопідогрелем</span> <span class=hps>(відповідно</span> <span class=hps>до затверджених</span> <span class=hps>показань</span> <span class=hps>до застосування</span> <span class=hps>даної комбінації</span> <span class=hps>у пацієнтів з</span> <span class=hps>гострим</span> <span class=hps>коронарним</span> <span class=hps>синдромом)</span>. <span class=hps>При</span> <span class=hps>необхідності одночасного застосування</span> <span class=hps>необхідний</span> <span class=hps>клінічний</span> <span class=hps>моніторинг</span> <span class=hps>за</span> <span class=hps>хворим.</span> </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>При</span></span><span lang=UK> <span class=hps>застосуванні з</span> <span class=hps>пеметрекседом</span> <span class=hps>у пацієнтів</span> <span class=hps>з нормальною</span> <span class=hps>функцією</span> <span class=hps>нирок</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>низькомолекулярним</span> <span class=hps>гепарином</span>, <span class=hps>нефракційним</span> <span class=hps>гепарином</span> <span class=hps>у пацієнтів до</span> <span class=hps>65</span> <span class=hps>років.</span> </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>тромболітиками</span>. </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span class=hps><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>пероральними</span> <span class=hps>антикоагулянтами</span> <span class=hps>в</span> <span class=hps>антиагрегантних</span> <span class=hps>дозах.<o:p></o:p></span></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>іншими</span> <span class=hps>нестероїдними</span> <span class=hps>протизапальними</span> <span class=hps>препаратами</span> <span class=hps>в</span> <span class=hps>антиагрегантних</span> <span class=hps>дозах.</span> </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l29 level1 lfo17;tab-stops:list 36.0pt'><![if !supportLists]><span class=hps><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span></span><![endif]><span class=hps><span lang=UK>Застосування з</span></span><span lang=UK> <span class=hps>глюкокортикостероїдами</span> <span class=hps>(крім</span> <span class=hps>замісної</span> <span class=hps>терапії</span>) і <span class=hps>анальгезуючими/</span> <span class=hps>жарознижувальними</span> <span class=hps>дозами.<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Особливості застосування.</span></i><span lang=UK> <o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Ацетилсаліцилову кислоту застосовують з обережністю у таких ситуаціях: </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l12 level1 lfo21;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>гіперчутливість до аналгетичних, протизапальних, протиревматичних засобів, а також за наявності алергії на інші речовини; </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l12 level1 lfo21;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>виразки шлунково-кишкового тракту, включаючи хронічну і рекуррентну виразкову хворобу або шлунково-кишкові кровотечі в анамнезі; </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l12 level1 lfo21;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>одночасне застосування антикоагулянтів;</span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l12 level1 lfo21;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>порушення функції нирок або порушення серцево-судинного кровообігу (наприклад патологія судин нирки, застійна серцева недостатність, гіповолемія, обширні операції, сепсис або сильні кровотечі), оскільки ацетилсаліцилова кислота може також збільшити ризик порушення функції нирок і розвитку гострої ниркової недостатності;</span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l12 level1 lfo21;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>важка недостатність глюкозо-6-фосфатдегідрогенази, оскільки ацетилсаліцилова кислота може викликати гемоліз або гемолітичну анемію, особливо при наявності факторів, які можуть збільшити ризик гемолізу, таких як високі дози препарату, лихоманка або гострий інфекційний процес; </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l12 level1 lfo21;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>порушення функції печінки. </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>У разі застосування Ацелізину перед початком прийому ібупрофену як знеболюючого засобу пацієнт повинен проконсультуватися з лікарем.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Ацетилсаліцилова кислота може обумовлювати розвиток бронхоспазму або нападу бронхіальної астми, або інші реакції підвищеної чутливості. Фактори ризику включають астму в анамнезі, сінну лихоманку, поліпи носа чи хронічні респіраторні захворювання, алергічні реакції (наприклад шкірні реакції, свербіж, кропив’янку) на інші речовини.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Через здатність ацетилсаліцилової кислоти пригнічувати агрегацію тромбоцитів, яка зберігається протягом кількох днів після прийому, застосування препаратів, що містять ацетилсаліцилову кислоту, може підвищити ймовірність/посилення кровотечі при хірургічних операціях (включаючи незначні хірургічні втручання, наприклад видалення зуба). <br> При застосуванні малих доз ацетилсаліцилової кислоти може знижуватися виведення сечової кислоти. Це може призвести до нападу подагри у схильних пацієнтів. <br> Регулярне використання анальгетиків може привести до стійких уражень нирок (з ризиком ниркової недостатності). </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>З обережністю застосовувати пацієнтам з гастритом в анамнезі, з метрорагією і/або менорагією. <br> Під час лікування препаратом в будь-який час можуть виникнути шлунково-кишкові кровотечі, виразки/перфорації, без наявності будь-яких станів в анамнезі пацієнта. Відносний ризик збільшується у літніх осіб, у пацієнтів з низькою масою тіла, у пацієнтів, які отримують антикоагулянти або інгібітори агрегації тромбоцитів. У разі виникнення шлунково-кишкових кровотеч лікування має бути негайно припинене. </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>При застосуванні високих протизапальних доз в ревматології, необхідно контролювати можливі ознаки передозування. У разі виникнення порушення слуху, шуму у вухах або запамороченні, потрібно переглянути лікування.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Застосування у період вагітності або годування груддю.</span></i><span lang=UK> <o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Пригнічення синтезу простагландинів може негативно вплинути на вагітність та/або ембріональний/внутрішньоутробний розвиток. Є дані про можливість ризику викидня і вад розвитку плоду після застосування інгібіторів синтезу простагландинів на початку вагітності. Ризик підвищується в залежності від збільшення дози і тривалості терапії. Згідно з наявними даними, зв’язок між прийомом ацетилсаліцилової кислоти і підвищеним ризиком викидня не підтверджена. </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Дані про виникнення вад розвитку не є послідовними, проте підвищений ризик гастрошизису не можна виключити при застосуванні ацетилсаліцилової кислоти. </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>В I і II триместрі вагітності препарати, що містять ацетилсаліцилову кислоту, не слід призначати без чіткої клінічної необхідності. Для жінок, у яких ймовірна вагітність або в першому і другому триместрі вагітності, доза препаратів, що містять ацетилсаліцилову кислоту, повинна бути якомога нижчою, а тривалість лікування коротшою.</span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><u><span lang=UK>Під час III триместру вагітності всі інгібітори синтезу простагландинів можуть впливати на плід наступним чином: <o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l27 level1 lfo22;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>серцево-легенева токсичність (з передчасним закриттям артеріальної протоки і легеневою гіпертензією); </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l27 level1 lfo22;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>порушення функції нирок з можливим подальшим розвитком ниркової недостатності з олігогідроамніозом. </span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><u><span lang=UK>На жінку і плід наприкінці вагітності – наступним чином: <o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l18 level1 lfo23;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>можливе збільшення часу кровотечі, антиагрегантний ефект, який може виникнути навіть після застосування дуже низьких доз; </span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l18 level1 lfo23;tab-stops:list 36.0pt'><![if !supportLists]><span lang=UK style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span lang=UK>гальмування скорочень матки, що може привести до затримки або збільшення тривалості пологів. </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Враховуючи це ацетилсаліцилова кислота протипоказана в III триместрі вагітності.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Ацетилсаліцилова кислота проникає в грудне молоко, тому її застосування під час лактації не рекомендується.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK style='mso-bidi-font-weight: bold'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Здатність впливати на швидкість реакції при керуванні автотранспортом або<span style='mso-spacerun:yes'> </span>іншими<span style='mso-spacerun:yes'> </span>механізмами.</span></i><span lang=UK> <o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>Не відзначалося</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>впливу</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>на</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>здатність керувати</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>автомобілем</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і працювати з</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>механізмами</span></span><span class=longtext><span lang=UK>.</span></span><span style='mso-ansi-language: RU;mso-bidi-font-weight:bold'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK style='mso-bidi-font-weight: bold'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Спосіб застосування та дози.</span></i><span lang=UK> <o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Застосовувати за призначенням і під контролем лікаря.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Ацелізин ввод</span><span style='mso-ansi-language:RU'>ити</span><span lang=UK> внутрішньом’язово (глибоко) і внутрішньовенно. Для внутрішньо-м’язового введення вміст флакона розчиняти безпосередньо перед застосуванням: <st1:metricconverter ProductID="1 г" w:st="on"><st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter><span style='mso-spacerun:yes'> </span></st1:metricconverter><span style='mso-spacerun:yes'> </span>(1 флакон) – у 5 мл води для ін'єкцій, збовтуючи до повного розчинення порошку.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Для профілактики тромбозу препарат вводити внутрішньом’язово (глибоко) по 0,5-3 мл розчину 1 раз на добу або через добу. Курс лікування – до 5 ін’єкцій, після чого, при необхідності, можна переходити на прийом пероральних форм кислоти ацетилсаліцилової. </span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Разову дозу і частоту повторних ін’єкцій препарату слід визначати враховуючи динаміку результатів лабораторного обстеження показників гемостазу після першого введення Ацелізину.</span></p> <p class=MsoBodyText><span lang=UK>При внутрішньовенному введенні Ацелізину для профілактики тромбозу перевага надається повільному вливанню препарату. Перед застосуванням <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> (1 флакон) розчиняти у 5 мл води для ін’єкцій, збовтуючи до повного розчинення порошку. Потім приготований розчин розв</span><span style='mso-ansi-language:RU'>одити</span><span lang=UK> в 150-200 мл 5 % розчину глюкози або 0,9 % розчину натрію хлориду та вводити зі швидкістю 1 мл/хвилину.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Для пацієнтів при больовому синдромі помірної сили, гарячкових станах, ревматичних захворюваннях, невритах рекомендується одноразове введення <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> Ацелізину. При сильних болях, колікоподібних болях разова доза може бути збільшена до <st1:metricconverter ProductID="2 г" w:st="on">2 г</st1:metricconverter>. При повторному застосуванні Ацелізину не слід перевищувати його добову дозу, яка становить <st1:metricconverter ProductID="10 г" w:st="on">10 г</st1:metricconverter>.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Курс лікування становить 3-10 днів.</span></p> <p class=MsoNormal style='text-align:justify;tab-stops:144.0pt'><b><i style='mso-bidi-font-style:normal'><span lang=UK><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;tab-stops:144.0pt'><b><i style='mso-bidi-font-style:normal'><span lang=UK>Діти.</span></i><span lang=UK> </span></b><span class=hps><span lang=UK>Ін’єкційна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>форма</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ацетилсаліцилової</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кислоти</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>не застосовується</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>у дітей.</span></span><span style='mso-ansi-language: RU;mso-bidi-font-weight:bold'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Передозування.</span></i><span lang=UK> <o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>Передозування</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>саліцилатами</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>можливе</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>внаслідок хронічної</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>інтоксикації</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>що виникла внаслідок</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>тривалої</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>терапії</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>(застосування</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>понад 100</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>мг/кг/добу більше</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>2</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>днів може</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>спричинити токсичні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ефекти</span></span><span class=longtext><span lang=UK>), </span></span><span class=hps><span lang=UK>а</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>також</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>через гостру</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>інтоксикацію</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>яка</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>несе</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>загрозу життю</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>(передозування</span></span><span class=longtext><span lang=UK>), </span></span><span class=hps><span lang=UK>причинами</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>якої можуть</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>бути</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>наприклад</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>випадкове</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>застосування</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>дітьми</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>або непередбачене</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>передозування</span></span><span class=longtext><span lang=UK>.<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>Хронічне отруєння</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>саліцилатами</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>може</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>мати</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>прихований</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>характер</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>оскільки його</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ознаки</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>неспецифічні.</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>Помірна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>хронічна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>інтоксикація</span></span><span class=longtext><span lang=UK>, викликана </span></span><span class=hps><span lang=UK>саліцилатами</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>або</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>саліцилізм</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>зустрічається</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>як</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>правило</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>тільки</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>після</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>повторних</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>прийомів</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>великих</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>доз</span></span><span class=longtext><span lang=UK>. <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>Симптоми</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>.</span></i><span lang=UK> </span></span><span class=hps><span lang=UK>Порушення</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>рівноваги</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>запаморочення</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>дзвін у</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>вухах</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>глухота</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>посилене</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>потовиділення</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>нудота</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>блювота</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>головний біль</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>сплутаність</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>свідомості.</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>Зазначені</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>симптоми</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>залежать від дози</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Дзвін у</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>вухах</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>може</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>відзначатися</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>при</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>концентрації</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>саліцилатів</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>в</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>плазмі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>крові</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>більше</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>150-300</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>мкг/мл</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Серйозні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>побічні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>реакції</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>зустрічаються</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>при</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>концентрації</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>саліцилатів</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>в</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>плазмі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>крові</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>більше 300</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>мкг/мл</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>При</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>важкому</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>отруєнні</span></span><span class=longtext><span lang=UK>: підвищення </span></span><span class=hps><span lang=UK>температури</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>кетоз</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>респіраторний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>алкалоз</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>метаболічний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ацидоз</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>кома</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>кардіоваскулярний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>колапс</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>дихальна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>недостатність</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>важка</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>гіпоглікемія, важка гіпокаліємія.</span></span><span class=longtext><span lang=UK> <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>Про</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>гостру інтоксикацію</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>свідчить</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>виражена зміна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кислотно</span></span><span class=atn><span lang=UK>-</span></span><span class=longtext><span lang=UK>лужного </span></span><span class=hps><span lang=UK>балансу</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>який може</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>відрізнятися</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>залежно</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>від</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>віку</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>тяжкості</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>інтоксикації</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Важкість</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>стану</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>не може</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>бути</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>визначена тільки</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>на</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>підставі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>концентрації</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>саліцилатів у</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>плазмі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>крові.</span></span><span class=longtext><span lang=UK> <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>Лікування</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>.</span></i><span lang=UK> </span></span><span class=hps><span lang=UK>Лікування</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>інтоксикації</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>викликаної</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>передозуванням</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ацетилсаліцилової</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кислоти</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>визначається</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ступенем</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>тяжкості</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>клінічними</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>симптомами</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>забезпечується</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>стандартними</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>методами</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>які</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>застосовують</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>при</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>отруєнні</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Всі вживані</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>заходи повинні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>бути спрямовані</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>на прискорення</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>видалення</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>препарату</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>та відновлення</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>електролітного</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кислотно</span></span><span class=atn><span lang=UK>-</span></span><span class=longtext><span lang=UK>лужного </span></span><span class=hps><span lang=UK>балансу</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Застосовують</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>активоване вугілля</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>форсований</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>лужний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>діурез</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Залежно</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>від стану</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кислотно</span></span><span class=atn><span lang=UK>-</span></span><span class=longtext><span lang=UK>лужної рівноваги </span></span><span class=hps><span lang=UK>та електролітного</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>балансу</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>проводять</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>інфузійне введення</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>розчинів</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>електролітів</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>При</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>серйозних</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>отруєннях</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>показаний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>гемодіаліз</span></span><span class=longtext><span lang=UK>.<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i style='mso-bidi-font-style: normal'><span lang=UK>Побічні реакції. <o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>При</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>застосуванні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>препарату</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>Ацелізин</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>можливі:</span></span><span class=longtext><span lang=UK> <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>з боку</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>шлунково</span></i></span><span class=atn><i style='mso-bidi-font-style:normal'><span lang=UK>-</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>кишкового </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>тракту</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>:</span></i><span lang=UK> </span></span><span class=hps><span lang=UK>ерозивно</span></span><span class=atn><span lang=UK>-</span></span><span class=longtext><span lang=UK>виразкові </span></span><span class=hps><span lang=UK>ураження</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>шлунково-кишкового тракту,</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>в</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>результаті</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>яких можливі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кровотеча</span></span><span class=longtext><span lang=UK>, перфорація, </span></span><span class=hps><span lang=UK>диспепсія</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>печія</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>болі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>в</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>животі</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>нудота</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>блювота</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>діарея</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>езофагіт</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>транзиторна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>печінкова</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>недостатність</span></span><span class=longtext><span lang=UK>;<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>з боку</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>крові та</span></i></span><span class=longtext><i style='mso-bidi-font-style: normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style: normal'><span lang=UK>кровотворення</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>:</span></i><span lang=UK> </span></span><span class=hps><span lang=UK>дуже</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>рідко</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>можуть</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>спостерігатися</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>тромбоцитопенія</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>постгеморагічна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>залізодефіцитна</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>анемія;<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>з боку імунної</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>системи:</span></i></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>алергічні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>реакції</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>включаючи</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>шкірні висипи</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>свербіж</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>кропив’янку</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>бронхоспазм</span></span><span class=longtext><span lang=UK>, загострення </span></span><span class=hps><span lang=UK>бронхіальної</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>астми</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>ангіоневротичний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>набряк</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>анафілаксія</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>включаючи</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>анафілактичний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>шок;<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>з боку</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>дихальної</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>системи</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>:</span></i><span lang=UK> </span></span><span class=hps><span lang=UK>закладеність</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>носа</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>риніт</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>набряк</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>легенів</span></span><span class=longtext><span lang=UK>;<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>з боку</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>органів</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>слуху</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK>:</span></i><span lang=UK> </span></span><span class=hps><span lang=UK>оборотні порушення</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>– шум</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>у вухах</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>втрата</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>слуху;<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>з боку</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>центральної і</span></i></span><span class=longtext><i style='mso-bidi-font-style: normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style: normal'><span lang=UK>периферичної</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>нервової</span></i></span><span class=longtext><i style='mso-bidi-font-style:normal'><span lang=UK> </span></i></span><span class=hps><i style='mso-bidi-font-style:normal'><span lang=UK>системи:</span></i><span lang=UK> головний</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>біль</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>запаморочення;</span></span><span class=longtext><span lang=UK> </span></span><span lang=UK><br> <span class=hps><i style='mso-bidi-font-style:normal'>інші</i></span><span class=longtext><i style='mso-bidi-font-style:normal'>:</i> </span><span class=hps>рідко</span><span class=longtext> </span><span class=hps>– гостра</span><span class=longtext> </span><span class=hps>ниркова</span><span class=longtext> </span><span class=hps>недостатність</span><span class=longtext>, </span><span class=hps>оборотні порушення</span><span class=longtext> </span><span class=hps>функції</span><span class=longtext> </span><span class=hps>нирок</span><span class=longtext> </span><span class=hps>і</span><span class=longtext> </span><span class=hps>печінки</span><span class=longtext>, </span><span class=hps>можливо</span><span class=longtext> </span><span class=hps>– виникнення</span><span class=longtext> </span><span class=hps>гепатотоксичності</span><span class=longtext>, </span><span class=hps>синдрому</span><span class=longtext> </span><span class=hps>Рейно</span><span class=longtext>, </span><span class=hps>реакції</span><span class=longtext> </span><span class=hps>в</span><span class=longtext> </span><span class=hps>місці введення</span><span class=longtext>, </span><span class=hps>включаючи біль</span><span class=longtext>. <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>Внаслідок</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>антиагрегантної дії</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>на</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>тромбоцити</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>ацетилсаліцилова</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кислота</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>може</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>асоціюватися</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>з ризиком</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>розвитку</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кровотеч</span></span><span class=longtext><span lang=UK>, збільшення часу </span></span><span class=hps><span lang=UK>кровотечі</span></span><span class=longtext><span lang=UK>. </span></span><span class=hps><span lang=UK>Спостерігалися</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>такі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кровотечі</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>як</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>периопераційні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>геморагії</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>гематоми</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>кровотечі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>з органів</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>сечостатевої</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>системи</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>носові</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кровотечі</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>кровотечі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>з ясен</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>пурпура</span></span><span class=longtext><span lang=UK>; </span></span><span class=hps><span lang=UK>серйозні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>кровотечі</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>такі</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>як</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>церебральні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>геморагії</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>(особливо</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>у пацієнтів</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>із неконтрольованою</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>гіпертензією</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>та/або</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>при</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>одночасному</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>застосуванні</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>антигемостатичних</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>засобів</span></span><span class=longtext><span lang=UK>), </span></span><span class=hps><span lang=UK>які</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>в</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>поодиноких випадках можуть</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>потенційно</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>загрожувати життю</span></span><span class=longtext><span lang=UK>. <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span class=hps><span lang=UK>Геморагії</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>можуть</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>призвести</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>до гострої</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>хронічної</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>постгеморагічної</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>анемії/залізодефіцитної</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>анемії</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>(внаслідок</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>так</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>званої</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>прихованої</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>мікрокровотечі</span></span><span class=longtext><span lang=UK>) </span></span><span class=hps><span lang=UK>з</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>відповідними</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>лабораторними</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>проявами</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>і</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>клінічними</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>симптомами</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>такими</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>як</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>астенія</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>блідість</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>шкірних</span></span><span class=longtext><span lang=UK> </span></span><span class=hps><span lang=UK>покривів</span></span><span class=longtext><span lang=UK>, </span></span><span class=hps><span lang=UK>гіпоперфузія</span></span><span class=longtext><span lang=UK>. </span></span><span lang=UK><br> <span class=hps>У пацієнтів з</span><span class=longtext> </span><span class=hps>тяжкими</span><span class=longtext> </span><span class=hps>формами</span><span class=longtext> </span><span class=hps>недостатності</span><span class=longtext> </span><span class=hps>глюкозо</span><span class=atn>-</span><span class=longtext>6</span><span class=atn>-</span><span class=longtext>фосфатдегідрогенази </span><span class=hps>спостерігалися</span><span class=longtext> </span><span class=hps>гемоліз</span><span class=longtext> </span><span class=hps>або</span><span class=longtext> </span><span class=hps>гемолітична</span><span class=longtext> </span><span class=hps>анемія.<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span lang=UK><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span lang=UK>Термін придатності.</span></i></b><span lang=UK> 2 роки.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK>Умови зберігання.</span></b><span lang=UK> В оригінальній упаковці при температурі від 2 °С до 8 °С.<span style='mso-spacerun:yes'> </span><span style='mso-bidi-font-style:italic'>Зберігати у недоступному для дітей місці. <o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK>Упаковка.</span></b><span lang=UK> По <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> у флаконах, по 10 флаконів у пачці; по <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> у флаконах.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-outline-level:1'><b style='mso-bidi-font-weight:normal'><span lang=UK>Категорія відпуску.</span></b><span lang=UK> За рецептом.</span></p> <p class=MsoNormal style='text-align:justify'><span lang=UK><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK>Виробник. </span></b><span lang=UK>ПАТ «Київмедпрепарат».</span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK>Місцезнаходження</span></b><b style='mso-bidi-font-weight:normal'><span style='mso-ansi-language:RU'> виро</span><span lang=UK>бника та його адреса місця провадження <span style='mso-spacerun:yes'> </span>діяльності.<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span lang=UK>Україна, <st1:metricconverter ProductID="01032, м" w:st="on">01032, м</st1:metricconverter>. Київ, вул. Саксаганського, 139.</span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span lang=UK><o:p> </o:p></span></b></p> <p class=MsoNormal><b><span lang=UK><o:p> </o:p></span></b></p> <b><span lang=UK style='font-size:12.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU;mso-bidi-language:AR-SA'><br clear=all style='mso-special-character:line-break; page-break-before:always'> </span></b> <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: none;punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family: "Times New Roman";mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: none;punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family: "Times New Roman";mso-ansi-language:RU'>ИНСТРУКЦИЯ</span></b><b style='mso-bidi-font-weight:normal'><span style='mso-bidi-font-size:10.0pt; font-family:"Times New Roman CYR","serif";mso-bidi-font-family:"Times New Roman"; mso-ansi-language:RU'><o:p></o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: none;punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family: "Times New Roman";mso-ansi-language:RU'>по медицинскому применению лекарственного средства<o:p></o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: none;punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-bidi-font-size:10.0pt;font-family:"Times New Roman CYR","serif"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: none;punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'>АЦЕЛИЗИН<o:p></o:p></span></b></p> <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: none;punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'>(<span style='mso-bidi-font-weight: bold'>ACELYSIN</span>)<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-bidi-font-size: 10.0pt;mso-ansi-language:RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='font-family:"Times New Roman CYR","serif"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:RU'>Состав:</span></i></b><b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'><span style='mso-bidi-font-size:10.0pt;font-family:"Times New Roman CYR","serif"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:RU'><o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family: "Times New Roman";mso-ansi-language:RU'>действующее вещество</span></i><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language:RU'>:</span></i><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family:"Times New Roman"; mso-ansi-language:RU'> </span><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language:RU'>ацелизин стерильный;<span style='mso-bidi-font-weight:bold;mso-bidi-font-style:italic'> <o:p></o:p></span></span></i></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>1 флакон содержит ацелизина стерильного – 1 г;<b><i><o:p></o:p></i></b></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-bidi-font-size: 10.0pt;mso-ansi-language:RU'><o:p> </o:p></span></p> <p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family:"Times New Roman"; mso-ansi-language:RU'>Лекарственная форма</span></b><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'>.</span></b><span style='mso-ansi-language: RU'> Порошок для раствора для инъекций.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>Основные физико-химические свойства:<b style='mso-bidi-font-weight: normal'> </b></span></i><span class=hps><span lang=UK>кристаллический</span></span><span lang=UK> <span class=hps>порошок</span> <span class=hps>белого</span> <span class=hps>цвета</span> <span class=hps>без</span> <span class=hps>запаха или со</span> <span class=hps>слабым специфическим</span> <span class=hps>запахом.<o:p></o:p></span></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-bidi-font-size: 10.0pt;mso-ansi-language:RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><span style='font-family:"Times New Roman CYR","serif";mso-bidi-font-family: "Times New Roman";mso-ansi-language:RU'>Фармакотерапевтическая группа.</span></b><span style='mso-ansi-language: RU'> Прочие анальгетики и антипиретики. Салициловая кислота и ее производные. Код АТХ N02B A01.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-bidi-font-size: 10.0pt;mso-ansi-language:RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Фармакологические свойства. <o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>Фармакодинамика</span></i><span style='mso-ansi-language:RU'>.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Ацелизин является инъекционной формой ацетилсалициловой кислоты и имеет характерные для нее свойства, а также повышает ее биодоступность и анальгетический эффект. Обладает анальгезирующим, противовоспалительным, жаропонижающим и антиагрегантным действием.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Препарат ингибирует циклооксигеназу, в результате чего угнетается синтез простагландинов и образование тромбоксана А<sub>2</sub> в тромбоцитах. Уменьшается способность тромбоцитов и эритроцитов к склеиванию и прилипанию (адгезии) к эндотелию кровеносных сосудов. Снижая поверхностное натяжение мембран эритроцитов, препарат облегчает их деформирование при прохождении через капилляры и улучшает кровоток.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>Фармакокинетика.<o:p></o:p></span></i></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Препарат связывается с белками плазмы на 80-90 %. Проникает в большинство тканей организма, в том числе в синовиальную, цереброспинальную, перитонеальную жидкости. В крови гидролизуется, образуя ацетилсалициловую кислоту и лизин. В печени ацетилсалициловая кислота превращается в салициловую. Период полувыведения ацетилсалициловой кислоты составляет 15-20 минут, салициловой и ее активных метаболитов – от 3-6 часов (малые дозы) до 15-30 часов (большие дозы). Экскретируется преимущественно почками в неизмененной форме (60 %) и в виде метаболитов.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'>Клинические характеристики.<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Показания.</span></i></b><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language:RU'> <o:p></o:p></span></i></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l16 level1 lfo2;tab-stops:list 18.0pt 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Болевой синдром различного генеза (головная, ушная и зубная боль, боли в послеоперационном периоде, а также при миалгии, артралгии, невралгии, невритах, коликоподобных болях, при ревматических заболеваниях);<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l16 level1 lfo2;tab-stops:list 18.0pt 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>лихорадочные состояния;<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l16 level1 lfo2;tab-stops:list 18.0pt 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>тромбофлебит поверхностных вен;<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:18.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l16 level1 lfo2;tab-stops:list 18.0pt 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>профилактика и лечение послеоперационных тромбозов и эмболий.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Противопоказания. </span></i></b><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'><o:p></o:p></span></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Гиперчувствительность к ацетилсалициловой кислоте, другим салицилатам или к любому компоненту препарата.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Бронхиальная астма, вызванная применением салицилатов или веществ с подобным действием, особенно НПВС, в анамнезе. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Острые желудочно-кишечные язвы.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Геморрагический диатез. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Почечная недостаточность тяжелой степени.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Печеночная недостаточность тяжелой степени.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Сердечная недостаточность тяжелой степени.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Комбинация с метотрексатом в дозировке 15 мг/неделю или больше.<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'><o:p></o:p></i></b></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l17 level1 lfo24;tab-stops:list 36.0pt;background:white'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Комбинация ацетилсалициловой кислоты в противовоспалительных/ жаропонижающих/анальгезирующих дозах с пероральными антикоагулянтами у больных с гастродуоденальной язвой в анамнезе.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Взаимодействие с другими лекарственными средствами и другие виды взаимодействий. <o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><u><span style='mso-ansi-language:RU'>Противопоказания для</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>одновременного применения</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>.<o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l3 level1 lfo25;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дозах</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>15</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>мг/неделю</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и более</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышает</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гематологическую токсичность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>(снижение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почечного</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>клиренса</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>противовоспалительными</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>агентами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и вытеснение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>салицилатами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата из</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>связи</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с белками</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>плазмы)</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>.</span><span style='mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l3 level1 lfo25;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение ацетилсалициловой кислоты с пероральными антикоагулянтами </span><span style='mso-ansi-language:RU'>в противовоспалительных/жаропонижающих/анальгезирующих дозах пациентам с гастродуоденальными язвами в анамнезе: повышенный риск кровотечения.<o:p></o:p></span></p> <p class=MsoNormal style='margin-right:8.75pt;text-align:justify'><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>Не рекомендованные комбинации.<o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение ацетилсалициловой кислоты с пероральными антикоагулянтами в </span><span style='mso-ansi-language:RU'>противовоспалительных/жаропонижающих/анальгезирующих дозах пациентам при отсутствии гастродуоденальных язв в анамнезе: повышенный риск возникновения кровотечения.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение ацетилсалициловой кислоты с пероральными антикоагулянтами в антиагрегантных дозах пациентам с гастродуоденальными язвами в анамнезе: повышенный риск кровотечений. </span><span style='mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Одновременное применение с низкомолекулярным гепарином, нефракционным гепарином у пациентов пожилого возраста (старше 65 лет) независимо от дозы гепарина и </span><span style='mso-ansi-language:RU'>противовоспалительных/жаропонижающих/анальгезирующих доз ацетилсалициловой кислоты.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с клопидогрелем (если нет утвержденных показаний к применению данной комбинации у пациентов с острым коронарным синдромом). <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение с тиклопидином, с урикозурическими лекарственными средствами. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение с глюкокортикоидами (кроме заместительной терапии) для противовоспалительных доз ацетилсалициловой кислоты.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:8.75pt;margin-bottom: 0cm;margin-left:36.0pt;margin-bottom:.0001pt;text-align:justify;text-indent: -18.0pt;mso-list:l20 level1 lfo26;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение с пеметрекседом у пациентов с легкой и умеренной почечной недостаточностью (клиренс креатинина между 45 мл/мин и 80 мл/мин): повышается риск токсичности пеметрекседа.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><u><span style='mso-ansi-language:RU'>Комбинации</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>, </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>которые</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>следует применять с</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>осторожностью.</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'><o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>При</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>применении</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дозах</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>менее <span style='mso-spacerun:yes'> </span>15</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>мг/неделю</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гематологическая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>токсичность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>(снижение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почечного</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>клиренса</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>противовоспалительными</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>агентами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и вытеснение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>салицилатами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>метотрексата из</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>связи</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с белками</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>плазмы)</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с ибупрофеном</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>препятствует</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>необратимому</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ингибированию</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>тромбоцитов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислотой.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>Лечение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ибупрофеном</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>пациентов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с риском</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кардиоваскулярных</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>заболеваний может</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ограничивать</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кардиопротекторное</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>действие</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и антикоагулянтов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>тромболитиков/других</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ингибиторов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>агрегации</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>тромбоцитов/гемостаза</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риск</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кровотечения.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>высоких</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>доз</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>салицилатов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с НПВП</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>(благодаря</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>взаимодополняющим</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эффектам)</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риск возникновения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>язв</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> желудочно-кишечного тракта </span><span style='mso-ansi-language: RU'>и желудочно-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>кишечных </span><span style='mso-ansi-language:RU'>кровотечений.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с селективными</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ингибиторами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>обратного захвата</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>серотонина (включая циталопрам, есциталопрам, флуоксетин, флувоксамин, пароксетин, сертралин) </span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><span style='mso-spacerun:yes'> </span></span><span style='mso-ansi-language: RU'>повышается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риск развития</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>желудочно-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>кишечного кровотечения </span><span style='mso-ansi-language:RU'>вследствие возможного</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эффекта</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>синергизма</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дигоксином</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> – </span><span style='mso-ansi-language:RU'>концентрация</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>последнего в</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>плазме</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вследствие снижения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почечной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>экскреции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>высоких</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>доз</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>противодиабетических</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>препаратов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>из группы</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>производных</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сульфонилмочевины</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>усиливается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гипогликемический</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эффект</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>последних</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>за счет вытеснения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сульфонилмочевины</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>связанной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с белками</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>плазмы</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислотой.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Диуретические</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>средства</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сочетании с высокими</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дозами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты снижают</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>клубочковую</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>фильтрацию</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>благодаря</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>снижению</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>синтеза</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>простагландинов в</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почках. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Системные</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>глюкокортикостероиды (</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>за исключением </span><span style='mso-ansi-language:RU'>гидрокортизона</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>который</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>применяют для</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>заместительной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>терапии</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>при</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>болезни</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>Аддисона</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>) снижают </span><span style='mso-ansi-language:RU'>уровень</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>салицилатов в</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>крови.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> Применение с кортикостероидами</span><span style='mso-ansi-language:RU'> повышается риск развития желудочно-кишечных кровотечений. </span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Ингибиторы АПФ</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> в </span><span style='mso-ansi-language:RU'>сочетании с высокими</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дозами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вызывают снижение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>фильтрации в</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>клубочках</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вследствие ингибирования</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вазодилататорного</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эффекта</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>простагландинов, а так же</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>снижение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>антигипертензивного</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эффекта. </span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вальпроевой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислотой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> – </span><span style='mso-ansi-language:RU'>ацетилсалициловая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислота</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вытесняет</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ее</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>из связи с</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>белками плазмы</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>повышая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>токсичность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>последней.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Алкоголь</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>способствует повреждению</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>слизистой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>оболочки</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>желудочно-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>кишечного </span><span style='mso-ansi-language:RU'>тракта и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>пролонгирует</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>время</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кровотечения вследствие</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>синергизма</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>алкоголя. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение мочегонных лекарственных средств, ингибиторов АПФ, антагонистов рецепторов ангиотензина ІІ с противовоспалительными/жаропонижающими/ анальгезирующими дозами ацетилсалициловой кислоты: риск острой почечной недостаточности. В начале лечения необходимо убедится, что у пациента нет обезвоживания и постоянно контролировать функции почек.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с клопидогрелем (в соответствии к утвержденным показаниям к применению данной комбинации у пациентов с острым коронарным синдромом). При необходимости сочетанного применения необходим клинический мониторинг за больным. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>При применении с пеметрекседом у пациентов с нормальной функцией почек.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>Применение с низкомолекулярным гепарином, нефракционным гепарином у пациентов до 65 лет</span><span style='mso-ansi-language:RU'>. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с тромболитиками. <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с пероральными антикоагулянтами в антиагрегантных дозах.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с другими нестероидными противовоспалительными препаратами в антиагрегантных дозах.<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l10 level1 lfo27;tab-stops:list 36.0pt'><![if !supportLists]><span style='font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family: Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>Применение с глюкокортикостероидами (кроме заместительной терапии) и анальгезирующими/жаропонижающими дозами.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><b><i><span style='mso-ansi-language: RU'>Особенности применения.</span></i></b><span style='mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Ацетилсалициловую</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоту</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>применяют с</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>осторожностью</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в следующих ситуациях:</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l6 level1 lfo28;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>гиперчувствительность к</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>анальгетическим</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>противовоспалительным</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>противоревматическим</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>средствам</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>а</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>также при наличии</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>аллергии на</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>другие вещества</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>;<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l6 level1 lfo28;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>язвы</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>желудочно-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>кишечного </span><span style='mso-ansi-language:RU'>тракта,</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>включая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>хроническую и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>рекуррентную</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>язвенную</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>болезнь или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>желудочно-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>кишечные </span><span style='mso-ansi-language:RU'>кровотечения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>анамнезе</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>; <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l6 level1 lfo28;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>о</span><span style='mso-ansi-language:RU'>дновременное применение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>антикоагулянтов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>; <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l6 level1 lfo28;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>н</span><span style='mso-ansi-language:RU'>арушение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>функции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почек</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или нарушение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сердечно-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>сосудистого </span><span style='mso-ansi-language:RU'>кровообращения (</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>например </span><span style='mso-ansi-language:RU'>патология</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сосудов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почки</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>застойная</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сердечная</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>недостаточность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>гиповолемия</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>обширные</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>операции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>сепсис</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или сильные</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кровотечения)</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>поскольку</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислота</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>может</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>также увеличить</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риск нарушения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>функции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почек</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и развития острой</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почечной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>недостаточности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>;<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l6 level1 lfo28;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>т</span><span style='mso-ansi-language:RU'>яжелая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>недостаточность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>глюкозо-6-</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>фосфатдегидрогеназы, </span><span style='mso-ansi-language:RU'>поскольку</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислота может вызвать</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гемолиз</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гемолитическую анемию</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>особенно при наличии</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>факторов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>которые могут увеличить</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риск</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гемолиза</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>таких как высокие</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дозы</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>препарата</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>лихорадка</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или острый</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>инфекционный</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>процесс</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>;<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l6 level1 lfo28;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>н</span><span style='mso-ansi-language:RU'>арушение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>функции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>печени.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>В</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>случае применения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU;mso-fareast-language:UK'>Ацелизина</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>перед</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>началом приема</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ибупрофена</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>как</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>обезболивающего</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>средства</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>пациент</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>должен</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>проконсультироваться</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с врачом.</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Ацетилсалициловая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислота</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>может обусловливать</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>развитие</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>бронхоспазма</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>приступа бронхиальной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>астмы,</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>другие реакции</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышенной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>чувствительности.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>Факторы риска включают</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>астму</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>анамнезе</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>сенную лихорадку</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>полипы носа или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>хронические</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>респираторные заболевания</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>аллергические</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>реакции (</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>например </span><span style='mso-ansi-language:RU'>кожные</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>реакции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>зуд</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>крапивницу</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>) на другие </span><span style='mso-ansi-language: RU'>вещества.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Из-за способности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>подавлять</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>агрегацию</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>тромбоцитов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>которая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сохраняется на протяжении</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>нескольких дней</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>после приема</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>применение препаратов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>содержащих ацетилсалициловую</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоту</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>может</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повысить</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вероятность/усиление</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кровотечения при</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>хирургических операциях</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>(включая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>незначительные</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>хирургические вмешательства</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>например</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>удаление зуба)</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'>. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>При</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>применении</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>малых</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>доз</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>может</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>снижаться</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>выведение мочевой</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>Это может</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>привести к приступу</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>подагры у</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>предрасположенных пациентов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:1.15pt;margin-bottom: 0cm;margin-left:1.15pt;margin-bottom:.0001pt;text-align:justify'><span style='mso-ansi-language:RU'>Регулярное использование анальгетиков может привести к стойким поражениям почек (с риском почечной недостаточности).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:1.15pt;margin-bottom: 0cm;margin-left:1.15pt;margin-bottom:.0001pt;text-align:justify'><span style='mso-ansi-language:RU'>С осторожностью применять пациентам с гастритом в анамнезе, с метроррагией и/или меноррагией. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:1.15pt;margin-bottom: 0cm;margin-left:1.15pt;margin-bottom:.0001pt;text-align:justify'><span style='mso-ansi-language:RU'>Во время лечения препаратом могут возникнуть желудочно-кишечные кровотечения, язвы/перфорации в любое время, без наличия каких-либо состояний в анамнезе пациента. Относительный риск увеличивается у пожилых лиц, у пациентов с низкой массой тела, у пациентов, получающих антикоагулянты или ингибиторы агрегации тромбоцитов. В случае возникновения желудочно-кишечных кровотечений лечение должно быть немедленно прекращено. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:0cm;margin-right:1.15pt;margin-bottom: 0cm;margin-left:1.15pt;margin-bottom:.0001pt;text-align:justify'><span style='mso-ansi-language:RU'>При применении высоких противовоспалительных доз в ревматологии, необходимо контролировать возможные<span style='mso-spacerun:yes'> </span>признаки передозировки. В случае возникновения нарушения слуха, шума в ушах или головокружении, нужно пересмотреть лечение.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><b><i><span style='mso-ansi-language:RU'><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><b><i><span style='mso-ansi-language:RU'>Применение в период беременности или кормления грудью</span></i></b><b><span style='mso-ansi-language:RU'>. <o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Угнетение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>синтеза</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>простагландинов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>может негативно</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повлиять</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>на беременность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и/или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эмбриональное/внутриутробное развитие</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>. </span><span style='mso-ansi-language:RU'>Есть данные о возможности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риска</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>выкидыша</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>пороков развития</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>плода</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>после применения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ингибиторов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>синтеза</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>простагландинов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в начале беременности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>. </span><span style='mso-ansi-language:RU'>Риск</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышается</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в зависимости</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>от увеличения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>дозы и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>продолжительности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>терапии.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>Согласно</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>имеющимся данным</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>связь</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>между</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>приемом</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышенным</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>риском</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>выкидыша</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>не подтверждена.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Данные</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>о возникновении</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>пороков развития</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>не являются</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>последовательными</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>однако</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>повышенный риск</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гастрошизиса</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>нельзя</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>исключить при</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>применении</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоты.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>В</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language: RU'> </span><span style='mso-ansi-language:RU'>I и</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>II</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>триместре</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>беременности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>препараты</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>содержащие</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловую</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоту</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>не следует</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>назначать</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>без</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>четкой</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>клинической</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>необходимости.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>Для</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>женщин, у которых</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>вероятна</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>беременность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в первом</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>втором</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>триместре</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>беременности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>доза препаратов</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>содержащих ацетилсалициловую</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислоту</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>должна</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>быть как можно</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ниже</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>а</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>продолжительность лечения</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>короче.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><u><span style='mso-ansi-language:RU'>Во время III</span></u></i><i style='mso-bidi-font-style: normal'><u><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>триместра</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>беременности</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>все</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>ингибиторы</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>синтеза</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>простагландинов</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>могут</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>влиять</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>на плод</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>следующим образом:</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> <o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l5 level1 lfo29;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>сердечно</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>-легочная </span><span style='mso-ansi-language:RU'>токсичность (</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>с преждевременным </span><span style='mso-ansi-language:RU'>закрытием</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>артериального протока</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и легочной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>гипертензией</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>); <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l5 level1 lfo29;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>нарушение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>функции</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почек</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>с возможным</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>последующим</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>развитием</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>почечной</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>недостаточности с</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>олигогидроамниозом</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><u><span style='mso-ansi-language:RU'>На женщину и</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>плод в</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>конце</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>беременности –</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-ansi-language:RU'>следующим образом:</span></u></i><i style='mso-bidi-font-style:normal'><u><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> <o:p></o:p></span></u></i></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l0 level1 lfo30;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>возможно</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>увеличение времени кровотечения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>антиагрегантный</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>эффект</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>который может</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>возникнуть даже</span><span style='mso-bidi-font-size:10.5pt; mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>после применения</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>очень</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>низких</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>доз</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>; <o:p></o:p></span></p> <p class=MsoNormal style='margin-left:36.0pt;text-align:justify;text-indent: -18.0pt;mso-list:l0 level1 lfo30;tab-stops:list 36.0pt'><![if !supportLists]><span style='mso-bidi-font-size:10.5pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:RU'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='mso-ansi-language:RU'>торможение</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>сокращений</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>матки</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>, </span><span style='mso-ansi-language:RU'>что может привести</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>к задержке</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>или</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>увеличения продолжительности</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>родов.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Учитывая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>это,</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>ацетилсалициловая</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>кислота</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>противопоказана</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>в</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>III</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>триместре</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>беременности.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Ацетилсалициловая кислота проникает в грудное молоко, поэтому ее применение во время лактации не рекомендуется.</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;tab-stops:276.0pt;background:white'><b><i><span style='mso-ansi-language:RU'><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;tab-stops:276.0pt;background:white'><b><i><span style='mso-ansi-language:RU'>Способность влиять на скорость реакции при управлении автотранспортом или другими<span style='mso-spacerun:yes'> </span>механизмами.<o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><span style='mso-ansi-language:RU'>Не отмечалось</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>влияния на способность</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>управлять</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>автомобилем</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>и</span><span style='mso-bidi-font-size: 10.5pt;mso-ansi-language:RU'> </span><span style='mso-ansi-language:RU'>работать с механизмами</span><span style='mso-bidi-font-size:10.5pt;mso-ansi-language:RU'>.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><span style='mso-ansi-language:RU;mso-fareast-language: UK'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Способ применения и дозы</span></i></b><b style='mso-bidi-font-weight:normal'><span style='mso-ansi-language:RU'>.</span></b><span style='mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-ansi-language: RU'>Применять по назначению и под контролем врача. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-ansi-language: RU'>Ацелизин вводить внутримышечно (глубоко) и внутривенно. Для внутримышечного введения содержимое <span style='mso-spacerun:yes'> </span>флакона <span style='mso-spacerun:yes'> </span>растворять <span style='mso-spacerun:yes'> </span>непосредственно <span style='mso-spacerun:yes'> </span>перед <span style='mso-spacerun:yes'> </span>применением: <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> (1 флакон) – в 5 мл воды для инъекций, взбалтывая до полного растворения порошка.<o:p></o:p></span></p> <p class=MsoBodyText><span style='mso-ansi-language:RU'>Для профилактики тромбоза препарат вводить внутримышечно (глубоко) по 0,5-3 мл раствора 1 раз в сутки или через сутки. Курс лечения – до 5 инъекций, после чего, при необходимости, можно переходить на прием пероральных форм кислоты ацетилсалициловой. Разовую дозу и частоту повторных инъекций препарата необходимо определять учитывая динамику результатов лабораторного обследования показателей гемостаза после первого введения Ацелизина.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>При внутривенном введении Ацелизина для профилактики тромбоза преимущество отдается медленному вливанию препарата. Перед применением <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> (1 флакон) растворяют в 5 мл воды для инъекций, взбалтывая до полного растворения порошка. Затем приготовленный раствор разводить в 150-200 мл 5 % раствора глюкозы или 0,9 % раствора натрия хлорида и вводить со скоростью 1 мл/минуту.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Для пациентов при болевом синдроме умеренной силы, лихорадочных состояниях, ревматических заболеваниях, невритах рекомендуется однократное введение <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> Ацелизина. При сильных болях, коликоподобных болях разовая доза может быть увеличена до <st1:metricconverter ProductID="2 г" w:st="on">2 г</st1:metricconverter>. При повторном применении Ацелизина не следует превышать его суточную дозу, которая составляет <st1:metricconverter ProductID="10 г" w:st="on">10 г</st1:metricconverter>.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Курс лечения составляет 3-10 дней.</span><span style='font-family:"Tahoma","sans-serif"; mso-ansi-language:RU'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-ansi-language: RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b><i><span style='mso-ansi-language: RU'>Дети. </span></i></b><span style='mso-ansi-language: RU'>Инъекционная форма ацетилсалициловой кислоты не применяется у детей.</span><span style='mso-ansi-language: RU;mso-fareast-language:UK'><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-ansi-language: RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Передозировка.</span></i></b><span style='mso-ansi-language:RU'> <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;background:white'><span style='mso-bidi-font-size:14.0pt;mso-ansi-language:RU'>Передозировка салицилатов возможна вследствие хронической интоксикации, возникшей вследствие длительной терапии (применение более 100 мг/кг/сутки более 2 дней может вызвать токсические эффекты), а также из-за острой интоксикации, которая несет угрозу жизни (передозировка), причинами которой могут быть, например, случайное применение детьми или непредвиденная передозировка.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;background:white'><span style='mso-bidi-font-size:14.0pt;mso-ansi-language:RU'>Хроническое отравление салицилатами может иметь скрытый характер, поскольку его признаки неспецифичны. Умеренная хроническая интоксикация, вызванная салицилатами, или салицилизм встречается, как правило, только после повторных приемов больших доз.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;background:white'><i style='mso-bidi-font-style:normal'><span style='mso-bidi-font-size:14.0pt; mso-ansi-language:RU'>Симптомы.</span></i><span style='mso-bidi-font-size:14.0pt;mso-ansi-language:RU'> Нарушение равновесия, головокружение, звон в ушах, глухота, усиленное потоотделение, тошнота и рвота, головная боль, спутанность сознания. Указанные симптомы дозозависимы. Звон в ушах может отмечаться при концентрации салицилатов в плазме крови более 150-300</span><span lang=UK style='mso-bidi-font-size:14.0pt'> </span><span style='mso-bidi-font-size: 14.0pt;mso-ansi-language:RU'>мкг/мл. Серьезные побочные реакции встречаются при концентрации салицилатов в плазме крови более 300 мкг/мл. При тяжелом отравлении: повышение температуры, кетоз, респираторный алкалоз, метаболический ацидоз, кома, кардиоваскулярный коллапс, дыхательная недостаточность, тяжелая гипогликемия, тяжелая гипокалиемия.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;background:white'><span style='mso-bidi-font-size:14.0pt;mso-ansi-language:RU'>Об острой интоксикации свидетельствует выраженное изменение кислотно-щелочного баланса, который может отличаться в зависимости от возраста и тяжести интоксикации. Тяжесть состояния не может быть определена только на основании концентрации салицилатов в плазме крови.<span style='mso-spacerun:yes'> </span><o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><i style='mso-bidi-font-style: normal'><span style='mso-bidi-font-size:14.0pt;mso-ansi-language:RU'>Лечение.</span></i><span style='mso-bidi-font-size:14.0pt;mso-ansi-language:RU'> Лечение интоксикации, вызванной передозировкой ацетилсалициловой кислоты, определяется степенью тяжести, клиническими симптомами и обеспечивается стандартными методами, которые применяют при отравлении. Все применяемые меры должны быть направлены на ускорение удаления препарата и восстановление электролитного и кислотно-щелочного баланса. Применяют активированный уголь, форсированный щелочной диурез. В зависимости от состояния кислотно-щелочного равновесия и электролитного баланса проводят инфузионное введение растворов электролитов. При серьезных отравлениях показан гемодиализ.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span style='mso-ansi-language: RU'>Побочные реакции. <o:p></o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-ansi-language: RU'>При применении препарата Ацелизин возможны:<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>со стороны желудочно-кишечного тракта:</span></i><span style='mso-ansi-language: RU'> эрозивно<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'>-</i></b>язвенные поражения желудочно-кишечного тракта в результате которых возможны кровотечение, перфорация; диспепсия, изжога,<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'> </i></b>боли в животе, тошнота, рвота, диарея, эзофагит, транзиторная печеночная недостаточность;<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>со стороны крови и кроветворения:</span></i><span style='mso-ansi-language:RU'> очень редко могут наблюдаться тромбоцитопения, постгеморрагическая железодефицитная анемия;<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>со стороны иммунной системы:</span></i><span style='mso-ansi-language:RU'> аллергические реакции, включая кожную сыпь, зуд, крапивницу, бронхоспазм, обострение бронхиальной астмы, ангионевротический отек; анафилаксия, включая анафилактический шок;<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>со стороны дыхательной системы</span></i><span style='mso-ansi-language:RU'>: заложенность носа, ринит, отек легких;<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'> <o:p></o:p></i></b></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>со стороны органов слуха:</span></i><span style='mso-ansi-language: RU'> обратимые нарушения – шум в ушах, потеря слуха; <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>со стороны центральной и периферической нервной системы:<b style='mso-bidi-font-weight: normal'> </b></span></i><span style='mso-ansi-language:RU'>головная боль, головокружение;<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><i style='mso-bidi-font-style: normal'><span style='mso-ansi-language:RU'>другие:</span></i><span style='mso-ansi-language:RU'> редко – острая почечная недостаточность, обратимые нарушения функции почек и печени, возможно – возникновение гепатотоксичности, синдрома Рейно; реакции в месте введения, включая боль. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Вследствие антиагрегатного действия на тромбоциты ацетилсалициловая кислота может ассоциироваться с риском развития кровотечений,<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'> </i></b>увеличение времени кровотечения.<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'> </i></b>Наблюдались такие кровотечения, как периоперационные геморрагии, гематомы, кровотечения из органов мочеполовой системы, носовые кровотечения, кровотечения из десен,<b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'> </i></b>пурпура;<b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'> </i></b>серьезные кровотечения, такие как церебральные геморрагии (особенно у пациентов с неконтролируемой гипертензией и/или при одновременном применении антигемостатичних средств), которые в редких случаях могут потенциально угрожать жизни. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'><span style='mso-ansi-language: RU'>Геморрагии могут привести к острой и хронической постгеморрагической анемии/ железодефицитной анемии (вследствие так называемого скрытого микрокровотечения) с соответствующими лабораторными проявлениями и клиническими симптомами, такими как астения, бледность кожных покровов, гипоперфузия. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><span style='mso-ansi-language: RU'>У пациентов с тяжелыми формами недостаточности глюкозо-6-фосфатдегидрогеназы наблюдались гемолиз или гемолитическая анемия.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b><i><span style='mso-ansi-language: RU'><o:p> </o:p></span></i></b></p> <p class=MsoNormal style='text-align:justify;background:white'><b><i><span style='mso-ansi-language:RU'>Срок годности. </span></i></b><span style='mso-ansi-language:RU'>2 года.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;line-height:13.9pt;mso-line-height-rule: exactly;background:white'><b><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify'><b><span style='mso-ansi-language: RU'>Условия хранения. </span></b><span style='mso-ansi-language:RU;mso-bidi-font-weight:bold'>В оригинальной упаковке<b> </b></span><span style='mso-ansi-language:RU'>при температуре от 2 °С до 8 °С.<span style='mso-spacerun:yes'> </span>Хранить в недоступном для детей месте. <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;background:white'><b style='mso-bidi-font-weight:normal'><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'>Упаковка. </span></b><span style='mso-ansi-language:RU'>По <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> во флаконах, по 10 флаконов в пачке; по <st1:metricconverter ProductID="1 г" w:st="on">1 г</st1:metricconverter> во флаконах.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-layout-grid-align:none; punctuation-wrap:simple;text-autospace:none'><b style='mso-bidi-font-weight: normal'><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify;background:white'><b style='mso-bidi-font-weight:normal'><span style='mso-ansi-language:RU'>Категория отпуска. </span></b><span style='mso-ansi-language:RU'>По рецепту.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><b><span style='mso-ansi-language:RU'><o:p> </o:p></span></b></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><b><span style='mso-ansi-language:RU'>Производитель. </span></b><span style='mso-ansi-language:RU;mso-bidi-font-weight:bold'>П</span><span style='mso-ansi-language:RU'>АО «Киевмедпрепарат». <o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify;line-height:13.7pt;mso-line-height-rule: exactly;background:white'><span style='mso-ansi-language:RU'><o:p> </o:p></span></p> <p class=MsoNormal style='text-align:justify;mso-pagination:none;background: white;mso-layout-grid-align:none;text-autospace:none'><b><span style='mso-ansi-language:RU'>Местонахождение производителя и его адрес места осуществления деятельности.<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify;mso-pagination:none;background: white;mso-layout-grid-align:none;text-autospace:none'><span style='font-family: "Times New Roman CYR","serif";mso-bidi-font-family:"Times New Roman"; mso-ansi-language:RU'>Украина, <st1:metricconverter ProductID="01032, г" w:st="on">01032, г</st1:metricconverter>. Киев, ул. Саксаганского, 139.</span><b><span style='mso-ansi-language:RU'><o:p></o:p></span></b></p> </div> </body> </html>